1FGV

X-RAY STRUCTURES OF FRAGMENTS FROM BINDING AND NONBINDING VERSIONS OF A HUMANIZED ANTI-CD18 ANTIBODY: STRUCTURAL INDICATIONS OF THE KEY ROLE OF VH RESIDUES 59 TO 65

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
A [auth L]d1fgvl_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin light chain kappa variable domain, VL-kappa human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)
B [auth H]d1fgvh_ All beta proteins Immunoglobulin-like beta-sandwich Immunoglobulin V set domains (antibody variable domain-like) Immunoglobulin heavy chain variable domain, VH human (Homo sapiens ) [TaxId: 9606 ], SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
A [auth L]V-sete1fgvL1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-setECOD (1.6)
B [auth H]V-set_12e1fgvH1 A: beta sandwichesX: Immunoglobulin-like beta-sandwichH: Immunoglobulin-relatedT: Immunoglobulin/Fibronectin type III/E set domains/PapD-likeF: V-set_12ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A [auth L]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)
B [auth H]2.60.40.10 Mainly Beta Sandwich Immunoglobulin-like ImmunoglobulinsCATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

ChainProtein NameDescriptionOrganism NameGene Allele Name(s)Domain Name(s)Receptor TypeReceptor DescriptionProvenance Source
A [auth L]Huh52-Aa-humanized V-KAPPA Humanized (humanized) IGKV1-33*01, IGKV1D-33*01, IGKV1-39*01, IGKV1D-39*01, IGKV1-NL1*01, IGKJ1*01, IGKJ4*01, IGKJ4*02 V-DOMAIN V-KAPPA IG FV-HEAVY_KAPPA IMGT (202449-0)
B [auth H]Huh52-Aa-humanized VH Humanized (humanized) IGHV3-74*01, IGHV3-74*02, IGHJ4*01, IGHJ4*02, IGHJ4*03 V-DOMAIN VH IG FV-HEAVY_KAPPA IMGT (202449-0)

SAbDab Antibody Annotation SAbDab Database Homepage

ChainChain ClassChain SubclassChain TypeAntigen Name(s) Provenance Source
A [auth L]Light ChainIGKV1 Kappa-SAbDab (2024-12-13)
B [auth H]Heavy ChainIGHV3 --SAbDab (2024-12-13)