1A3A | pdb_00001a3a

CRYSTAL STRUCTURE OF IIA MANNITOL FROM ESCHERICHIA COLI

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d1a3aa_	Alpha and beta proteins (a+b)	Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	IIA domain of mannitol-specific and ntr phosphotransferase EII	Phosphotransferase IIa-mannitol	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
B	d1a3ab_	Alpha and beta proteins (a+b)	Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	IIA domain of mannitol-specific and ntr phosphotransferase EII	Phosphotransferase IIa-mannitol	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
C	d1a3ac_	Alpha and beta proteins (a+b)	Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	IIA domain of mannitol-specific and ntr phosphotransferase EII	Phosphotransferase IIa-mannitol	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)
D	d1a3ad_	Alpha and beta proteins (a+b)	Phoshotransferase/anion transport protein	Phoshotransferase/anion transport protein	IIA domain of mannitol-specific and ntr phosphotransferase EII	Phosphotransferase IIa-mannitol	(Escherichia coli K-12 ) [TaxId: 83333 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	IIA domain of mannitol-specific and ntr phosphotransferase EII	8023750	4001876	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Phoshotransferase/anion transport protein	8036130	3000490	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Phoshotransferase/anion transport protein	8036130	3000490	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phoshotransferase/anion transport protein	8036130	3000490	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phoshotransferase/anion transport protein	8036130	3000490	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PTS_EIIA_2	e1a3aA1	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: PTS_EIIA_2	ECOD (1.6)
B	PTS_EIIA_2	e1a3aB1	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: PTS_EIIA_2	ECOD (1.6)
C	PTS_EIIA_2	e1a3aC1	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: PTS_EIIA_2	ECOD (1.6)
D	PTS_EIIA_2	e1a3aD1	A: a+b three layers	X: Phoshotransferase/anion transport protein (From Topology)	H: Phoshotransferase/anion transport protein (From Topology)	T: Phoshotransferase/anion transport protein	F: PTS_EIIA_2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.930.10	Alpha Beta	3-Layer(aba) Sandwich	Mannitol-specific EII	Chain A	CATH (4.3.0)
B	3.40.930.10	Alpha Beta	3-Layer(aba) Sandwich	Mannitol-specific EII	Chain A	CATH (4.3.0)
C	3.40.930.10	Alpha Beta	3-Layer(aba) Sandwich	Mannitol-specific EII	Chain A	CATH (4.3.0)
D	3.40.930.10	Alpha Beta	3-Layer(aba) Sandwich	Mannitol-specific EII	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00359	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2 (PTS_EIIA_2)	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2		Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	MANNITOL-SPECIFIC EII	kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups active transmembrane transporter activity protein-phosphocysteine-sugar phosphotransferase activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor mannitol transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity polyol transmembrane transporter activity protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups active transmembrane transporter activity protein-phosphocysteine-sugar phosphotransferase activity transporter activity carbohydrate transmembrane transporter activity transmembrane transporter activity phosphotransferase activity, alcohol group as acceptor mannitol transmembrane transporter activity protein-N(PI)-phosphohistidine-sugar phosphotransferase activity polyol transmembrane transporter activity protein-N(PI)-phosphohistidine-mannitol phosphotransferase system transmembrane transporter activity protein-phosphocysteine-mannitol phosphotransferase system transporter activity	transmembrane transport localization mannitol transmembrane transport transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport establishment of localization carbohydrate transmembrane transport import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system import across plasma membrane carbohydrate import across plasma membrane transmembrane transport localization mannitol transmembrane transport transport polyol transmembrane transport carbohydrate transport cellular process organic hydroxy compound transport establishment of localization carbohydrate transmembrane transport import into cell phosphoenolpyruvate-dependent sugar phosphotransferase system import across plasma membrane carbohydrate import across plasma membrane sorbitol transmembrane transport	cell periphery cellular anatomical structure plasma membrane membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR002178	PTS EIIA type-2 domain	Domain
A, B, C, D	IPR003501	Phosphotransferase system, EIIB component, type 2/3	Domain
A, B, C, D	IPR004718	Phosphotransferase system, mannitol-specific enzyme IIC	Domain
A, B, C, D	IPR036095	PTS system IIB component-like superfamily	Homologous Superfamily
A, B, C, D	IPR050893	Sugar Phosphotransferase System (PTS)	Family
A, B, C, D	IPR016152	Phosphotransferase/anion transporter	Homologous Superfamily
A, B, C, D	IPR029503	Phosphotransferase system EIIB component, mannitol-specific	Domain
A, B, C, D	IPR003352	Phosphotransferase system, EIIC	Domain
A, B, C, D	IPR013014	Phosphotransferase system, EIIC component, type 2	Domain
A, B, C, D	IPR013011	Phosphotransferase system, EIIB component, type 2	Domain

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.